NURS-6501C-13/NURS-6501N-13-Advanced Pathophysiology Midterm Exam
ORDER NURS-6501C-13/NURS-6501N-13-Advanced Pathophysiology Midterm Exam
What is the inflammatory effect of nitric oxide (NO)?
Increases capillary permeability, and causes pain | ||
Increases neutrophil chemotaxis and platelet aggregation | ||
Causes smooth muscle contraction and fever | ||
Decreases mast cell function, and decreases platelet aggregation |
D
In regulating vascular mediators released from mast cells, the role of eosinophils is to release what?
Arylsulfatase B, which stimulates the formation of B lymphocytes | ||
Histaminase, which limits the effects of histamine during acute inflammation | ||
Lysosomal enzymes, which activate mast cell degranulation during acute inflammation | ||
Immunoglobulin E, which defends the body against parasites |
B
In teaching a women’s community group, which risk factor does the healthcare professional teach is related to high morbidity of cancer of the colon, uterus, and kidney?
Women older than 45 years of age | ||
Women who have never had children | ||
Women who have a high body mass index | ||
Woman who have smoked for more than 10 years |
C
A student asks the professor to explain what effect natriuretic peptides have during heart failure when the heart dilates. Which response by the professor is best?
Stimulates antidiuretic hormones | ||
Inhibits antidiuretic hormones | ||
Stimulates renin and aldosterone | ||
Inhibits renin and aldosterone |
D
Decreased vagal stimulation increases the secretion of gastric acid
True
False
B
What organic compound facilitates transportation across cell membranes by acting as receptors, transport channels for electrolytes, and enzymes to drive active pumps?
Lipids | ||
Proteases | ||
Proteins | ||
Carbohydrates |
C
Acute mesenteric ischemia damages the intestinal mucosa and can eventually cause:
peritonitis | ||
malabsorption | ||
rupture | ||
appendicitis |
B
The increased renal excretion of sodium and water is caused by what substance?
Anti diuretic hormone | ||
Angiotenson | ||
Amino acids | ||
Natriuretic peptides |
D
Which of following is true about normal changes to the GI system that occur as individuals age?
decreased motility and increased liver blood flow and liver enzyme activity | ||
decreased motility and decreased liver blood flow and liver enzyme activity | ||
increased motility and decreased liver blood flow | ||
increased motility and increased liver enzyme activity |
B
Cells that metabolize nutrients, detoxify chemicals, secrete bile, synthesize albumin and clotting factors, and other functions are called?
Kupffer cells | ||
Pancreatic acinar cells | ||
Hepatocytes | ||
Parietal cells |
C
A patient had a motor vehicle crash and suffered critical injuries to the brainstem. What physiological responses would the healthcare professional expect to see?
Prolonged QRS segment | ||
Shortened PR interval | ||
Pulse and blood pressure changes | ||
Fluid overload |
C
During the cardiac cycle, why do the aortic and pulmonic valves close after the ventricles relax?
Papillary muscles relax, which allows the valves to close. | ||
Chordae tendineae contract, which pulls the valves closed. | ||
Reduced pressure in the ventricles creates a negative pressure, which pulls the valves closed. | ||
Blood fills the cusps of the valves and causes the edges to merge, closing the valves. |
D
An amniocentesis indicates a neural tube defect when an increase in which protein is evident?
Cytochrome P-450 | ||
Alpha fetoprotein | ||
DNA polymerase | ||
Embryonic proteins |
B
Which patient would the healthcare professional assess for other signs of thyrotoxic crisis?
Constipation with gastric distention | ||
Bradycardia and bradypnea | ||
Hyperthermia and tachycardia | ||
Constipation and lethargy |
c
A pregnant woman has Graves disease. What test/s does the healthcare professional advise the woman about?
Frequent tests of the newborn’s muscular strength and movement. | ||
Blood test for hyperthyroidism | ||
Monthly OB checkups for fetal anomalies or pregnancy loss | ||
Serum complete blood count including platelet count |
B
Which term is used to identify the movement of gas and air into and out of the lungs?
Perfusion | ||
Ventilation | ||
Respiration | ||
Diffusion |
B
Inflammation of the membranous sac that surrounds the heart is a description of which condition?
Pericarditis | ||
Varicose veins | ||
Intermittent claudication | ||
Thromboangiitis obliterans |
A
Parasympathetic nerves to the heart releases what the neurotransmitter?
serotonin | ||
epinephrine | ||
norepinephrine | ||
acetylcholine |
D
Which of the following laws is defined as “Within limits, a greater end-diastolic volume will produce a greater contractile force during systole”?
Laplace’s law | ||
Frank-Starling law | ||
Autonomic law | ||
Laplace’s law |
B
What is the single most common cause of cellular injury?
Hypoxic injury | ||
Chemical injury | ||
Infectious injury | ||
Genetic injury |
A
Cells that secrete digestive proenzymes are called?
Kupffer cells | ||
Pancreatic acinar cells | ||
Hepatocytes | ||
Parietal cells |
B
What causes the edema that occurs during the inflammatory process?
Vasodilation of blood vessels | ||
Increased capillary permeability | ||
Endothelial cell expansion | ||
Emigration of neutrophils |
B
People diagnosed with neurofibromatosis have varying degrees of the condition because of which genetic principle?
Penetrance | ||
Expressivity | ||
Dominance | ||
Recessiveness |
B
Which statement made by a student indicates the healthcare professional needs to describe the pericardium again?
The pericardium is a double-walled membranous sac that encloses the heart. | ||
It is made up of connective tissue and a surface layer of squamous cells. | ||
The pericardium protects the heart against infection and inflammation from the lungs and pleural space. | ||
It contains pain and mechanoreceptors that can elicit reflex changes in blood pressure and heart rate. |
B
A patient in the clinic reports projectile vomiting without nausea or other gastrointestinal symptoms. What action by the healthcare professional is most appropriate?
Provide antiemetic medications. | ||
Arrange a brain scan. | ||
Administer intravenous hydration. | ||
Schedule a GI consultation. |
B
The student asks the professor to explain what characteristic is demonstrated by lungs with decreased compliance?
Difficult deflation | ||
Easy inflation | ||
Stiffness | ||
Inability to diffuse oxygen |
C
A healthcare provider notes that tapping the patient’s facial nerve leads to lip twitching. What electrolyte value is correlated with this finding?
K +: 2.8 mEq/L | ||
K +: 5.4 mEq/L | ||
Ca ++: 8.2 mg/dL | ||
Ca ++: 12.9 mg/dL |
C
Neurotransmitters affect the postsynaptic membrane by binding to which structure?
Lipids | ||
Ribosomes | ||
Amphipathic lipids | ||
Receptors |
D
Acute rheumatic fever is a complication of a:
streptococcal infection of the pharynx | ||
staphylococcal infection of pharynx | ||
E. Coli infection of the kidney | ||
Pseudomonas infection of the lung |
A
Secretion of potassium, ammonia, and H1; site of action of aldosterone and ADH occurs in what portion of the kidney?
Proximal tubule | ||
Distal tubule and collecting duct | ||
Descending limb of loop of Henle | ||
Glomerulus |
B
What is the role of the normal intestinal bacterial flora?
Metabolizing bile salts, estrogens, and lipids | ||
Breaking down proteins into amino acids | ||
Facilitating the motility of the colon | ||
Metabolizing aldosterone and insulin |
A
Within a physiologic range, what does an increase in left ventricular end-diastolic volume (preload) result in?
Increase in force of contraction | ||
Decrease in refractory time | ||
Increase in afterload | ||
Decrease in repolarization |
A
The student asks the professor why water and electrolytes are transported in both directions through tight junctions and intercellular spaces rather than across cell membranes. What response by the professor is best?
The intercellular hydrostatic pressure is inadequate to push the water and electrolytes across the cell membranes. | ||
A balance of cations and ions among the electrolytes on each side of the cell membranes cannot be maintained. | ||
The epithelial cell membranes are formed of lipids that are hydrophobic and therefore repel water. | ||
Receptors on those cell membranes are occupied with a diffusion of amino acids and monosaccharides. |
C
Under anaerobic conditions, what process provides energy for the cell?
Oxidative phosphorylation | ||
Glycolysis | ||
Lactolysis | ||
Passive transport |
B
A patient is having a spirometry measurement done and asks the healthcare professional to explain this test. What response by the professional is best?
To evaluate the cause of hypoxia | ||
To measure the volume and flow rate during forced expiration | ||
To measure the gas diffusion rate at the alveolocapillary membrane | ||
To determine pH and oxygen and carbon dioxide concentrations |
B
A patient has been diagnosed with primary emphysema but claims there is no history of smoking. What action by the healthcare professional is most appropriate?
Facilitate genetic testing on the patient. | ||
Ask the family if the patient smokes. | ||
Schedule pulmonary function studies. | ||
Get baseline arterial blood gasses. |
A
What mechanisms occur in the liver cells as a result of lipid accumulation?
Accumulation of lipids that obstruct the common bile duct, preventing flow of bile from the liver to the gallbladder | ||
Increased synthesis of triglycerides from fatty acids and decreased synthesis of apoproteins | ||
Increased binding of lipids with apoproteins to form lipoproteins | ||
Increased conversion of fatty acids to phospholipids |
B
A patient had a thyroidectomy and now reports tingling around the mouth and has a positive Chvostek sign. What laboratory finding would be most helpful to the healthcare professional?
TSH and T 4 | ||
Serum sodium | ||
Serum calcium | ||
Urine osmolality |
C
Phagocytosis involves neutrophils actively attacking, engulfing, and destroying which microorganisms?
Bacteria | ||
Fungi | ||
Viruses | ||
Yeasts |
A
A patient has a peptic ulcer related to h. pylori bacteria. What treatment does the healthcare professional educate the patient on?
Antibiotic therapy | ||
Corticosteroids | ||
Vitamin B 12 injections | ||
Pancreatic enzyme replacement |
A
Which characteristic is the most important determinant of immunogenicity when considering the antigen?
Size | ||
Foreignness | ||
Complexity | ||
Quantity |
B
It has been determined that a patient’s tumor is in stage 2. How does the healthcare professional describe this finding to the patient?
Cancer is confined to the organ of origin. | ||
Cancer has spread to regional structures. | ||
Cancer is locally invasive. | ||
Cancer has spread to distant sites. |
C
Bile acid are recycled by the body and absorbed via:
portal circulation | ||
enterohepatic circulation | ||
biliary circulation | ||
splenic circulation |
A
The student wants information about a patient’s renal function. What test does the healthcare professional tell the student to evaluate?
Glomerular filtration rate | ||
Hourly urine output | ||
Serum blood urea nitrogen and creatinine | ||
The specific gravity of the solute concentration of the urine |
A
A student asks the healthcare professional to describe exotoxins. Which statement by the professional is best?
Exotoxins are contained in cell walls of gram-negative bacteria. | ||
Exotoxins are released during the lysis of bacteria. | ||
Exotoxins are able to initiate the complement and coagulation cascades. | ||
Exotoxins are released during bacterial growth. |
D
Which cAMP-mediated response is related to antidiuretic hormone?
Increased heart rate and force of contraction | ||
Secretion of cortisol | ||
Increased retention of water | ||
Breakdown of fat |
C
Collapse of alveoli is a(n):
Empyema | ||
Aspiration | ||
Atelectasis | ||
Hemoptysis |
C
Which type of immunity is produced by an individual after either natural exposure to the antigen or after immunization against the antigen?
Passive-acquired immunity | ||
Active-acquired immunity | ||
Passive-innate immunity | ||
Active-innate immunity |
B
A student asks the professor how a faulty negative-feedback mechanism results in a hormonal imbalance. What response by the professor is best?
Hormones are not synthesized in response to cellular and tissue activities. | ||
Decreased hormonal secretion is a response to rising hormone levels. | ||
Too little hormone production is initiated. | ||
Excessive hormone production results from a failure to turn off the system. |
D
A healthcare professional is conducting community education on vaccinations. Which statement about vaccines does the professional include in the presentation?
Most bacterial vaccines contain attenuated organisms. | ||
Most viral vaccines are made by using dead organisms. | ||
Vaccines require booster injections to maintain life-long protection. | ||
Vaccines provide effective protection against most infections. |
C
A healthcare professional is caring for four patients. Which patient should the professional assess for hyperkalemia?
Hyperparathyroidism | ||
Vomiting | ||
Renal failure | ||
Hyperaldosteronism |
C
If a patient develops acidosis, the nurse would expect the oxyhemoglobin dissociation curve to react in which manner?
Shift to the right, causing more oxygen (O 2) to be released to the cells | ||
Shift to the left, allowing less O 2 to be released to the cells | ||
Show no change, allowing the O 2 concentration to remain stable | ||
Show dramatic fluctuation, allowing the O 2 concentration to increase |
A
What is the major determinant of the resistance that blood encounters as it flows through the systemic circulation?
Volume of blood in the systemic circulation | ||
Muscle layer of the metarterioles | ||
Muscle layer of the arterioles | ||
Force of ventricular contraction |
C
The only manifestation of cystitis in an older adult may be development of:
confusion | ||
headache | ||
pelvic pain | ||
hypertension |
A
Parasympathetic stimulation causes airways to:
dilate | ||
constrict | ||
collapse | ||
trap air |
B
The concentration gradient of the renal interstitium increases from the cortex to the tip of the medulla, this causes the urine to:
Become more concentrated | ||
Become more dilute | ||
To leak through the basement membrane | ||
To help retain nutrients in the blood |
A
A healthcare professional is caring for four patients. Which patient does the professional assess for pulmonary emboli (PE) as the priority?
Deep venous thrombosis | ||
Endocarditis | ||
Valvular disease | ||
Left heart failure |
A
Hepatocytes synthesize the primary bile acids from _______________
cholesterol | ||
carbohydrates | ||
protein | ||
fat |
A
A patient’s urinalysis came back positive for glucose. What does the healthcare professional expect the patient’s blood glucose to be at a minimum?
126 mg/dL | ||
150 mg/dL | ||
180 mg/dL | ||
200 mg/dL |
C
The healthcare professional explains to a student that the amount of volume of blood in the heart is directly related to the _____ of contraction.
Pressure | ||
Strength | ||
Viscosity | ||
Speed |
B
What effect is a result of inhibiting the parasympathetic nervous system with a drug such as
Salivation becomes thinner. | ||
Salivation decreases. | ||
The pH of saliva changes. | ||
Digestive enzymes are inhibited. |
B
As a person ages, what type of changes occur in the myocardium and arterial walls?
dilation | ||
stiffening | ||
atrophy | ||
shrink |
B
The renal medulla recycles urea causing urine to become more:
contaminated | ||
filtered | ||
concentrated | ||
diluted |
C
Sympathetic stimulation of the renal arterioles causes what reaction?
fluid excretion | ||
diuresis | ||
vasodilation | ||
vasoconstriction |
D
What is the only surface inside the nephron where cells are covered with microvilli to increase the reabsorptive surface area called?
Proximal convoluted tubules | ||
Distal tubules | ||
Ascending loop of Henle | ||
Descending loop of Henle |
A
After a partial gastrectomy, gastric bypass, or pyloroplasty, clinical manifestations that include increased pulse, hypotension, weakness, pallor, sweating, and dizziness are the results of which mechanism?
Excessive relaxation of gastric and vascular smooth muscles | ||
Postoperative hemorrhage | ||
Concentrated food bolus, causing hyperglycemia | ||
Rapid gastric emptying |
D
A pancreatic enzyme that digests proteins is called ___________________
Trypsin | ||
Amylase | ||
Pepsin | ||
Ptyalin |
A
A healthcare professional wants to determine the adequacy of a person’s alveolar ventilation. What assessment finding is most important for the professional to consider?
Respiratory rate of 12 breaths/min | ||
Ventilatory pattern is regular and rhythmic. | ||
Respiratory effort is strained with muscle involvement. | ||
Arterial blood gas shows a PaCO 2 of 44 mmHg. |
D
A student asks why some vaccinations are given orally and some are given by injection. What response by the professor is best?
Different routes allow the speed of onset of the antigen to be varied, with the intravenous route being the fastest. | ||
Some individuals appear to be unable to respond to an antigen by a specific route, thus requiring the availability of different routes for the same antigen. | ||
Antigen-presenting cells are highly specialized and thus require stimulation by different routes. | ||
Each route stimulates a different lymphocyte-containing tissue, resulting in different types of cellular and humoral immunity. |
D
The healthcare professional working with older adults teaches general infection-prevention measures as a priority for this age group due to which change in lymphocyte function?
Increased production of antibodies against self-antigens | ||
Decreased number of circulating T cells | ||
Decreased production of autoantibodies | ||
Increased production of helper T cells |
A
A patient has a history of excessive use of magnesium-containing antacids and aluminum-containing antacids. What lab value does the healthcare professional correlate to this behavior?
Magnesium 1.8 mg/dL | ||
Phosphate 1.9 mg/dL | ||
Sodium 149 mEq/L | ||
Potassium 2.5 mEq/L |
B
Vitamin D is activated by the kidneys and is stimulated by what hormone?
calcitonin | ||
ADH | ||
parathyroid hormone | ||
natriuretic peptides |
C
A patient has diabetes mellitus. A recent urinalysis showed increased amounts of protein. What therapy does the healthcare provider educate the patient that is specific to this disorder?
More frequent blood glucose monitoring | ||
Moderate dietary sodium restriction | ||
Treatment with an ACE inhibitor | ||
Home blood pressure monitoring |
C
What is one function of the tumor cell marker?
To provide a definitive diagnosis of cancer | ||
To treat certain types of cancer | ||
To predict where cancers will develop | ||
To screen individuals at high risk for cancer |
D
The external urethral sphincter is under the voluntary control of what somatic motor nerve?
pudendal | ||
phrenic | ||
sacral | ||
femoral |
A
A patient with severe colicky flank pain radiating to the groin, nausea and vomiting, and some hematuria is experiencing classic symptoms of:
Renal cancer | ||
Nephrotic syndrome | ||
Calculus lodged in ureter | ||
Acute kidney injury |
C
Women who have symptoms of cystitis for more than 6 weeks with negative urine cultures may have:
aseptic cystitis | ||
interstitial cystitis | ||
septic cystitis | ||
pyelonephritis |
B
What hormone delay gastric emptying?
gastrin and motilin | ||
gastrin and cholecystokinin | ||
secretin and cholecystokinin | ||
secretin and motilin |
C
A person has hypothyroidism. What chemical does the healthcare professional advise the person to include in the diet?
Iron | ||
Iodine | ||
Zinc | ||
Magnesium |
B
A professor has taught a student about skeletal alterations seen in chronic kidney disease. Which statement by the student indicates the professor needs to give more information?
Parathyroid hormone is no longer effective in maintaining serum phosphate levels. | ||
The parathyroid gland is no longer able to secrete sufficient parathyroid hormone. | ||
The synthesis of 1,25-vitamin D 3, which reduces intestinal absorption of calcium, is impaired. | ||
The effectiveness of calcium and phosphate resorption from bone is impaired. |
B
A patient that is hyperventilating will have a decreased:
saturation | ||
Pa02 | ||
PaCO2 | ||
minute volume |
C
A patient is brought to the Emergency Department with a gunshot wound to the chest. The healthcare professional assesses an abnormality involving a pleural rupture that acts as a one-way valve, permitting air to enter on inspiration but preventing its escape by closing during expiration. What action by the healthcare professional is the priority?
Draw arterial blood gasses. | ||
Assist with a chest tube insertion. | ||
Give the patient low-flow oxygen. | ||
Assess for clubbing of fingernails. |
B
A patient has a pulmonary capillary wedge pressure of 30mmHg. What assessment finding by the healthcare professional would be most consistent with this reading?
Normal lung sounds | ||
Pink, frothy sputum | ||
Eupnea | ||
Rhonchi |
B
During cell injury caused by hypoxia, why does an increase in the osmotic pressure within the cell occur?
Plasma proteins enter the cell. | ||
The adenosine triphosphatase (ATPase)-driven pump is stronger during hypoxia. | ||
Sodium chloride enters the cell. | ||
An influx of glucose occurs through the injured cell membranes. |
C
A healthcare professional is assessing a child whose parents report poor grades in school, trouble paying attention, and naughty behaviors that have become so frequent the child is always in trouble. For which health condition should the professional facilitate testing?
Hypoxic injury | ||
Lead poisoning | ||
Mercury exposure | ||
Cadmium injection |
B
Sympathetic stimulation causes airways to:
dilate | ||
constrict | ||
collapse | ||
trap air |
A
A patient with hematuria, dull flank pain, weight loss and anemia in the late stages of the disease are experiencing classic symptoms of:
Renal cancer | ||
Nephrotic syndrome | ||
Calculus lodged in ureter | ||
Acute kidney injury |
A
Oxygenated blood flows through which vessel?
Superior vena cava | ||
Pulmonary veins | ||
Pulmonary artery | ||
Coronary veins |
B
Renal failure is the most common cause of which type of hyperparathyroidism?
Primary | ||
Secondary | ||
Exogenous | ||
Inflammatory |
B
What are blood pressure variations associated with?
b 1-Adrenergic receptors to increase heart rate | ||
The release of an antidiuretic hormone (ADH) | ||
The renin-angiotensin system’s effect on vasoconstriction | ||
Serum bradykinin, causing vasodilation |
C
A person wants to know if eating only plant-based foods is advisable as a way to cut cholesterol to near-zero levels. What response by the health care professional is best?
No, you will become extremely malnourished. | ||
Yes, that is an effective way to eliminate cholesterol. | ||
No, many hormones are made from cholesterol. | ||
Yes, that will increase the action of insulin. |
C
The presence of pus in the pleural cavity is a(n):
Empyema | ||
Atelectasis | ||
Aspiration | ||
Hemoptysis |
A
The action of platelet-derived growth factor is to stimulate the production of which cells?
Platelets | ||
Epidermal cells | ||
Connective tissue cells | ||
Fibroblast cells |
C
Cells that secrete hydrochloric acid and intrinsic factor are called?
Kupffer cells | ||
Pancreatic acinar cells | ||
Hepatocytes | ||
Parietal cells |
D
What pathologic change occurs to the kidney’s glomeruli as a result of hypertension?
Compression of the renal tubules | ||
Ischemia of the tubule | ||
Increased pressure from within the tubule | ||
Obstruction of the renal tubule |
B
A student learns what information about acute pancreatitis?
Autoimmune process with IgG attacking pancreatic acinar cells | ||
It is usually a severe disease with a high mortality rate. | ||
Pancreatic enzymes autodigest pancreatic cells and tissues. | ||
Oversecretion of pancreatic enzymes and malnutrition |
C
The functional glomeruli are located in what part of the kidney?
cortex | ||
medulla | ||
epithelium | ||
Hiluh |
A
A patient diagnosed with diabetic ketoacidosis (DKA) has the following laboratory values: arterial pH 7.20; serum glucose 500 mg/dL; positive urine glucose and ketones; serum potassium (K +) 2 mEq/L; serum sodium (Na +) 130 mEq/L. The patient reports that he has been sick with the flu for 1 week. What relationship do these values have to his insulin deficiency?
Increased glucose use causes the shift of fluid from the intravascular to the intracellular space. | ||
Decreased glucose use causes fatty acid use, ketogenesis, metabolic acidosis, and osmotic diuresis. | ||
Increased glucose and fatty acids stimulate renal diuresis, electrolyte loss, and metabolic alkalosis. | ||
Decreased glucose use results in protein catabolism, tissue wasting, respiratory acidosis, and electrolyte loss. |
B
A patient asks the healthcare professional why tissue damage occurs in acute rejection after organ transplantation. What response by the professional is best?
Th1 cells release cytokines that activate infiltrating macrophages, and cytotoxic T cells directly attack the endothelial cells of the transplanted tissue. | ||
Circulating immune complexes are deposited in the endothelial cells of transplanted tissue, where the complement cascade lyses tissue. | ||
Receptors on natural killer cells recognize antigens on the cell surface of transplanted tissue, which releases lysosomal enzymes that destroy tissue. | ||
Antibodies coat the surface of transplanted tissue to which mast cells bind and liberate preformed chemical mediators that destroy tissue. |
A
When completing this exam, did you comply with Walden University’s Code of Conduct including the expectations for academic integrity?
Yes | ||||||||||||||||||||||||||
No | ||||||||||||||||||||||||||
A woman who loses a small amount of urine involuntarily every time she sneezes is experiencing what type of incontinence?
C A patient’s urinalysis came back positive for glucose. What does the healthcare professional expect the patient’s blood glucose to be at a minimum?
C |
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