NURS-6501C-13/NURS-6501N-13-Advanced Pathophysiology Midterm Exam

NURS-6501C-13/NURS-6501N-13-Advanced Pathophysiology Midterm Exam

ORDER NURS-6501C-13/NURS-6501N-13-Advanced Pathophysiology Midterm Exam

What is the inflammatory effect of nitric oxide (NO)?

  Increases capillary permeability, and causes pain
  Increases neutrophil chemotaxis and platelet aggregation
  Causes smooth muscle contraction and fever
  Decreases mast cell function, and decreases platelet aggregation

D

In regulating vascular mediators released from mast cells, the role of eosinophils is to release what?

  Arylsulfatase B, which stimulates the formation of B lymphocytes
  Histaminase, which limits the effects of histamine during acute inflammation
  Lysosomal enzymes, which activate mast cell degranulation during acute inflammation
  Immunoglobulin E, which defends the body against parasites

B

In teaching a women’s community group, which risk factor does the healthcare professional teach is related to high morbidity of cancer of the colon, uterus, and kidney?

  Women older than 45 years of age
  Women who have never had children
  Women who have a high body mass index
  Woman who have smoked for more than 10 years

C

A student asks the professor to explain what effect natriuretic peptides have during heart failure when the heart dilates. Which response by the professor is best?

  Stimulates antidiuretic hormones
  Inhibits antidiuretic hormones
  Stimulates renin and aldosterone
  Inhibits renin and aldosterone

D

Decreased vagal stimulation increases the secretion of gastric acid

True

False

B

What organic compound facilitates transportation across cell membranes by acting as receptors, transport channels for electrolytes, and enzymes to drive active pumps?

  Lipids
  Proteases
  Proteins
  Carbohydrates

C

Acute mesenteric ischemia damages the intestinal mucosa and can eventually cause:

  peritonitis
  malabsorption
  rupture
  appendicitis

B

The increased renal excretion of sodium and water  is caused by what substance?

  Anti diuretic hormone
  Angiotenson
  Amino acids
  Natriuretic peptides

D

Which of following is true about normal changes to the GI system that occur as individuals age?

  decreased motility and increased liver blood flow and liver enzyme activity
  decreased motility and  decreased liver blood flow and liver enzyme activity
  increased motility and decreased liver blood flow
  increased motility and increased liver enzyme activity

B

Cells that  metabolize nutrients, detoxify chemicals, secrete bile, synthesize albumin and clotting factors, and other functions are called?

  Kupffer cells
  Pancreatic acinar cells
  Hepatocytes
  Parietal cells

C

A patient had a motor vehicle crash and suffered critical injuries to the brainstem. What physiological responses would the healthcare professional expect to see?

  Prolonged QRS segment
  Shortened PR interval
  Pulse and blood pressure changes
  Fluid overload

C

During the cardiac cycle, why do the aortic and pulmonic valves close after the ventricles relax?

  Papillary muscles relax, which allows the valves to close.
  Chordae tendineae contract, which pulls the valves closed.
  Reduced pressure in the ventricles creates a negative pressure, which pulls the valves closed.
  Blood fills the cusps of the valves and causes the edges to merge, closing the valves.

D

An amniocentesis indicates a neural tube defect when an increase in which protein is evident?

  Cytochrome P-450
  Alpha fetoprotein
  DNA polymerase
  Embryonic proteins

B

Which patient would the healthcare professional assess for other signs of thyrotoxic crisis?

  Constipation with gastric distention
  Bradycardia and bradypnea
  Hyperthermia and tachycardia
  Constipation and lethargy

c

A pregnant woman has Graves disease. What test/s does the healthcare professional advise the woman about?

  Frequent tests of the newborn’s muscular strength and movement.
  Blood test for hyperthyroidism
  Monthly OB checkups for fetal anomalies or pregnancy loss
  Serum complete blood count including platelet count

B

Which term is used to identify the movement of gas and air into and out of the lungs?

  Perfusion
  Ventilation
  Respiration
  Diffusion

B

Inflammation of the membranous sac that surrounds the heart is a description of which condition?

   Pericarditis
  Varicose veins
   Intermittent claudication
  Thromboangiitis obliterans

A

Parasympathetic nerves to the heart releases what  the neurotransmitter?

  serotonin
  epinephrine
  norepinephrine
  acetylcholine

D

Which of the following laws is defined as “Within limits, a greater end-diastolic volume will produce a greater contractile force during systole”?

  Laplace’s law
  Frank-Starling law
  Autonomic law
  Laplace’s law

B

What is the single most common cause of cellular injury?

  Hypoxic injury
  Chemical injury
  Infectious injury
  Genetic injury

A

Cells that  secrete digestive proenzymes are called?

  Kupffer cells
  Pancreatic acinar cells
  Hepatocytes
  Parietal cells

B

What causes the edema that occurs during the inflammatory process?

  Vasodilation of blood vessels
  Increased capillary permeability
  Endothelial cell expansion
  Emigration of neutrophils

B

People diagnosed with neurofibromatosis have varying degrees of the condition because of which genetic principle?

  Penetrance
  Expressivity
  Dominance
  Recessiveness

B

Which statement made by a student indicates the healthcare professional needs to describe the pericardium again?

  The pericardium is a double-walled membranous sac that encloses the heart.
  It is made up of connective tissue and a surface layer of squamous cells.
  The pericardium protects the heart against infection and inflammation from the lungs and pleural space.
  It contains pain and mechanoreceptors that can elicit reflex changes in blood pressure and heart rate.

B

A patient in the clinic reports projectile vomiting without nausea or other gastrointestinal symptoms. What action by the healthcare professional is most appropriate?

  Provide antiemetic medications.
  Arrange a brain scan.
  Administer intravenous hydration.
  Schedule a GI consultation.

B

The student asks the professor to explain what characteristic is demonstrated by lungs with decreased compliance?

  Difficult deflation
  Easy inflation
  Stiffness
  Inability to diffuse oxygen

C

A healthcare provider notes that tapping the patient’s facial nerve leads to lip twitching. What electrolyte value is correlated with this finding?

  +: 2.8 mEq/L
  +: 5.4 mEq/L
  Ca ++: 8.2 mg/dL
  Ca ++: 12.9 mg/dL

C

Neurotransmitters affect the postsynaptic membrane by binding to which structure?

  Lipids
  Ribosomes
  Amphipathic lipids
  Receptors

D

Acute rheumatic fever is a complication of  a:

  streptococcal infection of the pharynx
  staphylococcal infection of pharynx
  E. Coli infection of the kidney
  Pseudomonas infection of the lung

A

Secretion of potassium, ammonia, and H1; site of action of aldosterone and ADH occurs in what portion of the kidney?

  Proximal tubule
  Distal tubule and collecting duct
  Descending limb of loop of Henle
  Glomerulus

B

What is the role of the normal intestinal bacterial flora?

  Metabolizing bile salts, estrogens, and lipids
  Breaking down proteins into amino acids
  Facilitating the motility of the colon
  Metabolizing aldosterone and insulin

A

Within a physiologic range, what does an increase in left ventricular end-diastolic volume (preload) result in?

  Increase in force of contraction
  Decrease in refractory time
  Increase in afterload
  Decrease in repolarization

A

The student asks the professor why water and electrolytes are transported in both directions through tight junctions and intercellular spaces rather than across cell membranes. What response by the professor is best?

  The intercellular hydrostatic pressure is inadequate to push the water and electrolytes across the cell membranes.
  A balance of cations and ions among the electrolytes on each side of the cell membranes cannot be maintained.
  The epithelial cell membranes are formed of lipids that are hydrophobic and therefore repel water.
  Receptors on those cell membranes are occupied with a diffusion of amino acids and monosaccharides.

C

Under anaerobic conditions, what process provides energy for the cell?

  Oxidative phosphorylation
  Glycolysis
  Lactolysis
  Passive transport

B

A patient is having a spirometry measurement done and asks the healthcare professional to explain this test. What response by the professional is best?

  To evaluate the cause of hypoxia
  To measure the volume and flow rate during forced expiration
  To measure the gas diffusion rate at the alveolocapillary membrane
  To determine pH and oxygen and carbon dioxide concentrations

B

A patient has been diagnosed with primary emphysema but claims there is no history of smoking. What action by the healthcare professional is most appropriate?

  Facilitate genetic testing on the patient.
  Ask the family if the patient smokes.
  Schedule pulmonary function studies.
  Get baseline arterial blood gasses.

A

What mechanisms occur in the liver cells as a result of lipid accumulation?

  Accumulation of lipids that obstruct the common bile duct, preventing flow of bile from the liver to the gallbladder
  Increased synthesis of triglycerides from fatty acids and decreased synthesis of apoproteins
  Increased binding of lipids with apoproteins to form lipoproteins
  Increased conversion of fatty acids to phospholipids

B

A patient had a thyroidectomy and now reports tingling around the mouth and has a positive Chvostek sign. What laboratory finding would be most helpful to the healthcare professional?

  TSH and T 4
  Serum sodium
  Serum calcium
  Urine osmolality

C

Phagocytosis involves neutrophils actively attacking, engulfing, and destroying which microorganisms?

  Bacteria
  Fungi
  Viruses
  Yeasts

A

A patient has a peptic ulcer related to h. pylori bacteria. What treatment does the healthcare professional educate the patient on?

  Antibiotic therapy
  Corticosteroids
  Vitamin B 12 injections
  Pancreatic enzyme replacement

A

Which characteristic is the most important determinant of immunogenicity when considering the antigen?

  Size
  Foreignness
  Complexity
  Quantity

B

It has been determined that a patient’s tumor is in stage 2. How does the healthcare professional describe this finding to the patient?

  Cancer is confined to the organ of origin.
  Cancer has spread to regional structures.
  Cancer is locally invasive.
  Cancer has spread to distant sites.

C

Bile acid are recycled by the body and absorbed via:

  portal circulation
  enterohepatic circulation
  biliary circulation
  splenic circulation

A

The student wants information about a patient’s renal function. What test does the healthcare professional tell the student to evaluate?

  Glomerular filtration rate
  Hourly urine output
  Serum blood urea nitrogen and creatinine
  The specific gravity of the solute concentration of the urine

A

A student asks the healthcare professional to describe exotoxins. Which statement by the professional is best?

  Exotoxins are contained in cell walls of gram-negative bacteria.
  Exotoxins are released during the lysis of bacteria.
  Exotoxins are able to initiate the complement and coagulation cascades.
  Exotoxins are released during bacterial growth.

D

Which cAMP-mediated response is related to antidiuretic hormone?

  Increased heart rate and force of contraction
  Secretion of cortisol
  Increased retention of water
  Breakdown of fat

C

Collapse of alveoli is a(n):

  Empyema
  Aspiration
  Atelectasis
  Hemoptysis

C

Which type of immunity is produced by an individual after either natural exposure to the antigen or after immunization against the antigen?

  Passive-acquired immunity
  Active-acquired immunity
  Passive-innate immunity
  Active-innate immunity

B

A student asks the professor how a faulty negative-feedback mechanism results in a hormonal imbalance. What response by the professor is best?

  Hormones are not synthesized in response to cellular and tissue activities.
  Decreased hormonal secretion is a response to rising hormone levels.
  Too little hormone production is initiated.
  Excessive hormone production results from a failure to turn off the system.

D

A healthcare professional is conducting community education on vaccinations. Which statement about vaccines does the professional include in the presentation?

  Most bacterial vaccines contain attenuated organisms.
  Most viral vaccines are made by using dead organisms.
  Vaccines require booster injections to maintain life-long protection.
  Vaccines provide effective protection against most infections.

C

A healthcare professional is caring for four patients. Which patient should the professional assess for hyperkalemia?

  Hyperparathyroidism
  Vomiting
  Renal failure
  Hyperaldosteronism

C

If a patient develops acidosis, the nurse would expect the oxyhemoglobin dissociation curve to react in which manner?

  Shift to the right, causing more oxygen (O 2) to be released to the cells
  Shift to the left, allowing less O 2 to be released to the cells
  Show no change, allowing the O 2 concentration to remain stable
  Show dramatic fluctuation, allowing the O 2 concentration to increase

A

What is the major determinant of the resistance that blood encounters as it flows through the systemic circulation?

  Volume of blood in the systemic circulation
  Muscle layer of the metarterioles
  Muscle layer of the arterioles
  Force of ventricular contraction

C

The only manifestation of cystitis in an older adult may be development of:

  confusion
  headache
  pelvic pain
  hypertension

A

Parasympathetic stimulation causes airways to:

  dilate
  constrict
  collapse
  trap air

B

The concentration gradient of the renal interstitium increases from the cortex to the tip of the medulla, this causes the urine to:

  Become more concentrated
  Become more dilute
  To leak through the basement membrane
  To help retain nutrients in the blood

A

A healthcare professional is caring for four patients. Which patient does the professional assess for pulmonary emboli (PE) as the priority?

  Deep venous thrombosis
  Endocarditis
  Valvular disease
  Left heart failure

A

Hepatocytes synthesize the primary bile acids from _______________

  cholesterol
  carbohydrates
  protein
  fat

A

A patient’s urinalysis came back positive for glucose. What does the healthcare professional expect the patient’s blood glucose to be at a minimum?

  126 mg/dL
  150 mg/dL
  180 mg/dL
  200 mg/dL

C

The healthcare professional explains to a student that the amount of volume of blood in the heart is directly related to the _____ of contraction.

  Pressure
  Strength
  Viscosity
  Speed

B

What effect is a result of inhibiting the parasympathetic nervous system with a drug such as

  Salivation becomes thinner.
  Salivation decreases.
  The pH of saliva changes.
  Digestive enzymes are inhibited.

B

As a person ages, what type of changes occur in the  myocardium and arterial walls?

  dilation
  stiffening
  atrophy
  shrink

B

The renal medulla recycles urea causing urine to become more:

  contaminated
  filtered
  concentrated
  diluted

C

Sympathetic stimulation of the renal arterioles causes what reaction?

  fluid  excretion
  diuresis
  vasodilation
  vasoconstriction

D

What is the only surface inside the nephron where cells are covered with microvilli to increase the reabsorptive surface area called?

  Proximal convoluted tubules
  Distal tubules
  Ascending loop of Henle
  Descending loop of Henle

A

After a partial gastrectomy, gastric bypass, or pyloroplasty, clinical manifestations that include increased pulse, hypotension, weakness, pallor, sweating, and dizziness are the results of which mechanism?

  Excessive relaxation of gastric and vascular smooth muscles
  Postoperative hemorrhage
  Concentrated food bolus, causing hyperglycemia
  Rapid gastric emptying

D

A pancreatic enzyme that digests proteins is called ___________________

  Trypsin
  Amylase
  Pepsin
  Ptyalin

A

A healthcare professional wants to determine the adequacy of a person’s alveolar ventilation. What assessment finding is most important for the professional to consider?

  Respiratory rate of 12 breaths/min
  Ventilatory pattern is regular and rhythmic.
  Respiratory effort is strained with muscle involvement.
  Arterial blood gas shows a PaCO 2 of 44 mmHg.

D

A student asks why some vaccinations are given orally and some are given by injection. What response by the professor is best?

  Different routes allow the speed of onset of the antigen to be varied, with the intravenous route being the fastest.
  Some individuals appear to be unable to respond to an antigen by a specific route, thus requiring the availability of different routes for the same antigen.
  Antigen-presenting cells are highly specialized and thus require stimulation by different routes.
  Each route stimulates a different lymphocyte-containing tissue, resulting in different types of cellular and humoral immunity.

D

The healthcare professional working with older adults teaches general infection-prevention measures as a priority for this age group due to which change in lymphocyte function?

  Increased production of antibodies against self-antigens
  Decreased number of circulating T cells
  Decreased production of autoantibodies
  Increased production of helper T cells

A

A patient has a history of excessive use of magnesium-containing antacids and aluminum-containing antacids. What lab value does the healthcare professional correlate to this behavior?

  Magnesium 1.8 mg/dL
  Phosphate 1.9 mg/dL
  Sodium 149 mEq/L
  Potassium 2.5 mEq/L

B

Vitamin D is activated by the kidneys and is stimulated by what hormone?

  calcitonin
  ADH
  parathyroid hormone
  natriuretic peptides

C

A patient has diabetes mellitus. A recent urinalysis showed increased amounts of protein. What therapy does the healthcare provider educate the patient that is specific to this disorder?

  More frequent blood glucose monitoring
  Moderate dietary sodium restriction
  Treatment with an ACE inhibitor
  Home blood pressure monitoring

C

What is one function of the tumor cell marker?

  To provide a definitive diagnosis of cancer
  To treat certain types of cancer
  To predict where cancers will develop
  To screen individuals at high risk for cancer

D

The external urethral sphincter is under the voluntary control of what somatic motor nerve?

  pudendal
  phrenic
  sacral
  femoral

A

A patient with severe colicky flank pain radiating to the groin, nausea and vomiting,  and some hematuria is experiencing classic symptoms of:

  Renal cancer
  Nephrotic syndrome
  Calculus lodged in ureter
  Acute kidney injury

C

Women who have symptoms of cystitis for more than 6 weeks with negative urine cultures may have:

  aseptic  cystitis
  interstitial  cystitis
  septic  cystitis
  pyelonephritis

B

What hormone delay gastric emptying?

  gastrin and motilin
  gastrin and cholecystokinin
  secretin and cholecystokinin
  secretin and motilin

C

A person has hypothyroidism. What chemical does the healthcare professional advise the person to include in the diet?

  Iron
  Iodine
  Zinc
  Magnesium

B

A professor has taught a student about skeletal alterations seen in chronic kidney disease. Which statement by the student indicates the professor needs to give more information?

  Parathyroid hormone is no longer effective in maintaining serum phosphate levels.
  The parathyroid gland is no longer able to secrete sufficient parathyroid hormone.
  The synthesis of 1,25-vitamin D 3, which reduces intestinal absorption of calcium, is impaired.
  The effectiveness of calcium and phosphate resorption from bone is impaired.

B

A patient that is hyperventilating will have a decreased:

  saturation
  Pa02
  PaCO2
  minute volume

C

A patient is brought to the Emergency Department with a gunshot wound to the chest. The healthcare professional assesses an abnormality involving a pleural rupture that acts as a one-way valve, permitting air to enter on inspiration but preventing its escape by closing during expiration. What action by the healthcare professional is the priority?

  Draw arterial blood gasses.
  Assist with a chest tube insertion.
  Give the patient low-flow oxygen.
  Assess for clubbing of fingernails.

B

A patient has a pulmonary capillary wedge pressure of 30mmHg. What assessment finding by the healthcare professional would be most consistent with this reading?

  Normal lung sounds
  Pink, frothy sputum
  Eupnea
  Rhonchi

B

During cell injury caused by hypoxia, why does an increase in the osmotic pressure within the cell occur?

  Plasma proteins enter the cell.
  The adenosine triphosphatase (ATPase)-driven pump is stronger during hypoxia.
  Sodium chloride enters the cell.
  An influx of glucose occurs through the injured cell membranes.

C

A healthcare professional is assessing a child whose parents report poor grades in school, trouble paying attention, and naughty behaviors that have become so frequent the child is always in trouble. For which health condition should the professional facilitate testing?

  Hypoxic injury
  Lead poisoning
  Mercury exposure
  Cadmium injection

B

Sympathetic stimulation causes airways to:

  dilate
  constrict
  collapse
  trap air

A

A patient with hematuria, dull flank pain, weight loss and anemia in the late stages of the disease are experiencing classic symptoms of:

  Renal cancer
  Nephrotic syndrome
  Calculus lodged in ureter
  Acute kidney injury

A

Oxygenated blood flows through which vessel?

  Superior vena cava
  Pulmonary veins
  Pulmonary artery
  Coronary veins

B

Renal failure is the most common cause of which type of hyperparathyroidism?

  Primary
  Secondary
  Exogenous
  Inflammatory

B

What are blood pressure variations associated with?

  1-Adrenergic receptors to increase heart rate
  The release of an antidiuretic hormone (ADH)
  The renin-angiotensin system’s effect on vasoconstriction
  Serum bradykinin, causing vasodilation

C

A person wants to know if eating only plant-based foods is advisable as a way to cut cholesterol to near-zero levels. What response by the health care professional is best?

  No, you will become extremely malnourished.
  Yes, that is an effective way to eliminate cholesterol.
  No, many hormones are made from cholesterol.
  Yes, that will increase the action of insulin.

C

The presence of pus in the pleural cavity is a(n):

  Empyema
  Atelectasis
  Aspiration
  Hemoptysis

A

The action of platelet-derived growth factor is to stimulate the production of which cells?

  Platelets
  Epidermal cells
  Connective tissue cells
  Fibroblast cells

C

Cells that secrete hydrochloric acid and intrinsic factor are called?

  Kupffer cells
  Pancreatic acinar cells
  Hepatocytes
  Parietal cells

D

What pathologic change occurs to the kidney’s glomeruli as a result of hypertension?

  Compression of the renal tubules
  Ischemia of the tubule
  Increased pressure from within the tubule
  Obstruction of the renal tubule

B

A student learns what information about acute pancreatitis?

  Autoimmune process with IgG attacking pancreatic acinar cells
  It is usually a severe disease with a high mortality rate.
  Pancreatic enzymes autodigest pancreatic cells and tissues.
  Oversecretion of pancreatic enzymes and malnutrition

C

The functional glomeruli are located in what part of the kidney?

  cortex
  medulla
  epithelium
  Hiluh

A

A patient diagnosed with diabetic ketoacidosis (DKA) has the following laboratory values: arterial pH 7.20; serum glucose 500 mg/dL; positive urine glucose and ketones; serum potassium (K +) 2 mEq/L; serum sodium (Na +) 130 mEq/L. The patient reports that he has been sick with the flu for 1 week. What relationship do these values have to his insulin deficiency?

  Increased glucose use causes the shift of fluid from the intravascular to the intracellular space.
  Decreased glucose use causes fatty acid use, ketogenesis, metabolic acidosis, and osmotic diuresis.
  Increased glucose and fatty acids stimulate renal diuresis, electrolyte loss, and metabolic alkalosis.
  Decreased glucose use results in protein catabolism, tissue wasting, respiratory acidosis, and electrolyte loss.

B

A patient asks the healthcare professional why tissue damage occurs in acute rejection after organ transplantation. What response by the professional is best?

  Th1 cells release cytokines that activate infiltrating macrophages, and cytotoxic T cells directly attack the endothelial cells of the transplanted tissue.
  Circulating immune complexes are deposited in the endothelial cells of transplanted tissue, where the complement cascade lyses tissue.
  Receptors on natural killer cells recognize antigens on the cell surface of transplanted tissue, which releases lysosomal enzymes that destroy tissue.
  Antibodies coat the surface of transplanted tissue to which mast cells bind and liberate preformed chemical mediators that destroy tissue.

A

When completing this exam, did you comply with Walden University’s Code of Conduct including the expectations for academic integrity?

  Yes
  No

A woman who loses a small amount of urine involuntarily every time she sneezes is experiencing what type of incontinence?

  Functional incontinence
  Overflow incontinence
  Stress incontinence
  Urge incontinence

C

A patient’s urinalysis came back positive for glucose. What does the healthcare professional expect the patient’s blood glucose to be at a minimum?

  126 mg/dL
  150 mg/dL
  180 mg/dL
  200 mg/dL

C

  

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